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Joint health, Liver support, Mood support
Adults seeking a simple once-daily option for methylation support and those with active or busy lifestyles looking for joint and liver wellness support.
Take 1 tablet once daily, with or without food; if you experience stomach sensitivity, consider taking with a meal.
Suitable for Vegetarians; Formulated without Gluten, GMOs, or Soy; Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten; Produced in a facility that may process other products containing these allergens.
SAMe donates methyl groups used in methylation reactions that influence neurotransmitter synthesis, liver antioxidant capacity, and connective tissue components like collagen.
Caution: May interact with medications that affect neurotransmitters such as SSRIs, MAO inhibitors, or L-Dopa because it can influence neurotransmitter pathways; may cause digestive upset or headaches in some people, so start with the suggested serving and take with food if sensitive; not advised for those with bipolar disorder or Parkinson’s disease due to mood and dopamine effects; avoid during pregnancy and breastfeeding due to limited safety data.
Label Warning: Do not use if pregnant or nursing. Consult a physician before use if taking L-Dopa or antidepressants such as SSRIs or MAO inhibitors. Do not use if you have Parkinson’s disease, bipolar disorder, or manic depression. Do not exceed the recommended intake. May cause headaches and gastrointestinal discomfort such as diarrhea, gas, or nausea; discontinue if these occur.
Who should be cautious: People sensitive to serotonin changes, or with mood instability, should be cautious. Those with liver or gastrointestinal concerns may wish to start with a lower amount and monitor tolerance. If using antidepressants or L-Dopa, discuss with a healthcare provider before use.
Storage: Store in a cool, dry place. Protect from heat, light, and moisture.
Many users mention a brighter mood and better sleep quality after consistent use.
Several reviewers report reduced joint discomfort and easier movement.
A few users did not notice clear benefits or felt demotivated and sluggish.
This product is guaranteed authentic and backed by our easy returns & refunds policy. Details
Glucosamine and chondroitin may support joint health and flexibility, complementing SAM-e's potential benefits for joint comfort.
AI generated. Not medical advice.
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SAMe (S-Adenosyl Methionine) is a compound that is used by the body to produce and regulate hormones and maintain cell membranes. Though the body can produce SAMe on its own, California Gold Nutrition SAMe, can help keep levels at an optimal level, which can help support healthy joints, liver, and mood.*
Benefits of S-Adenosyl Methionine
S-Adenosyl Methionine, or SAMe, can provide numerous benefits when taken as a supplement. This compound may help support healthy inflammatory processes in the body and also help stimulate collagen production, thus assisting with joint mobility and function.* It also facilitates healthy methylation enzymatic processes as well as increases levels of hepatic glutathione, an antioxidant that is vital to a healthy liver.* Lastly, SAMe methylation reactions are involved in the synthesis of neurotransmitters such as dopamine, epinephrine, phosphatidylcholine, and serotonin, which may support a healthy mood.*
California Gold Nutrition SAMe contains S-Adenosyl Methionine that is produced in a temperature-controlled (low temperature-low humidity) environment, using a proprietary fermentation process to ensure high (S,S) Isomer levels. The tablets are enteric coated and are double-foil blister sealed ensuring product integrity and protection from light, moisture and oxygen.
Take 1 tablet daily, with or without food. Best when taken as directed by a qualified healthcare professional.
Main Ingredients
SAMe (S-Adenosyl Methionine) (from 800 mg of Ademetionine 1,4-Butanedisulfonate)
Other Ingredients
Microcrystalline Cellulose, Croscarmellose Sodium, Ascorbyl Palmitate, Silicon Dioxide (Silica), Ascorbic Acid, Citric Acid and Enteric Coating (Methacrylic Acid Copolymer, Hydroxypropyl Methylcellulose, Polyethylene Glycol, Triacetin, Titanium Dioxide, Riboflavin.
Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, and cGMP-compliant facility that may process other products that contain these allergens or ingredients.
Keep out of the reach of children. Do not use if pregnant or nursing. Individuals using physician-prescribed medications such as L-Dopa or Antidepressants (e.g., Selective Serotonin Re-Uptake Inhibitors [SSRIs] and MAO Inhibitors) should consult a physician before using SAMe. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. Do not exceed recommended intake. Please consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
NOTE: SAMe may cause headaches & gastrointestinal disturbances (e.g., diarrhea, flatulence & nausea) in some individuals. Please discontinue use if you experience any of these issues.
Individually Double-Foil Blister Sealed for quality and your protection. Do not use if Blister Pack material is punctured or missing. Store in a cool dry place. Protect from heat, light, and moisture.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.
| Supplement facts | ||
| Serving Size: 1 Tablet | ||
| Servings Per Container: 60 | ||
| Amount Per Serving | %Daily Value | |
| SAMe (S-Adenosyl Methionine) (from 800 mg of Ademetionine 1,4-Butanedisulfonate) | 400 mg | † |
| † Daily Value not established. | ||
